Insulin receptor substrate-1 G972R single nucleotide polymorphism in Egyptian patients with chronic hepatitis C virus infection and type 2 diabetes mellitus
نویسندگان
چکیده
Abstract Background Insulin receptor substrate-1 (IRS1) plays a critical role in insulin signaling. IRS-1 gene polymorphism with glycine to arginine substitution (GGG ↔ AGG substitutions) codon 972 (G972R) (rs1801278) is common of the gene, which may have pathogenic development type 2 diabetes mellitus (type DM) due resistance and impaired secretion. In hepatitis C virus infection (HCV), IRS proteins might be counter-regulated by degradation, differential expression, or modification phosphorylation cells expressing HCV core protein, inhibits interactions both downstream effectors IRS-1. The present retrospective case–control study aimed evaluate G972R (rs 1801278) SNP Egyptian patients DM, two hundred subjects including 100 males 102 females work detect chronic DM. were divided into control group (group I) included 50 apparently healthy volunteers comparable age, gender, socioeconomic status patients; II diabetic without infection; III 52 HCV-infected mellitus; IV C-infected mellitus. genotyping was done using polymerase chain reaction (PCR-RFLP) technique restriction enzymes BstNI. Results HOMA-IR QUICKI index significantly higher patient groups (groups II, III, IV) than controls ( P < 0.001, = 0.019, 0.001 respectively). There significant increase minor allele (A) 0.007, 0.017, 0.007 increased frequency mutant wild (G) BMI 25 kg/m . DM II), III), showed decrease GG genotypes AA 0.009 Body mass waist hip ratio II) controls, 0.001). Conclusion contributing risk factor for suggests this as factors even normal body weight. an independent
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ژورنال
عنوان ژورنال: Egyptian Liver Journal
سال: 2021
ISSN: ['2090-6226', '2090-6218']
DOI: https://doi.org/10.1186/s43066-020-00069-1